.Attributes Medication, Released online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic analyses showed that a novel reassortant virus-like descent of the Oropouche infection, which has actually been circulating in the western Amazon.com area of South america for about a decade, is associated with the current human outbreaks between 2022 and 2024.